NPTE Plan

NPTE practice question: System Interactions

System InteractionsDifficulty 3/5

A 68-year-old with a history of breast cancer reports two weeks of thoracic pain, worse at night, unrelieved by position change, with unintentional weight loss. What is the appropriate action?

  1. ABegin thoracic mobilisation and postural retraining, then reassess
  2. BRefer for medical evaluation before initiating physical therapy treatment
  3. CApply modalities for pain relief and review the response in one week
  4. DPrescribe a home exercise programme and follow up in two weeks
Show answer and rationale

Correct: B. Cancer history, night pain unrelieved by position and unexplained weight loss are red flags for metastatic disease. Referral precedes treatment, however mechanical the presentation appears.

  • A — Mobilisation could be harmful in the presence of possible bony metastases.
  • C — Symptomatic relief delays diagnosis of a potentially serious condition.
  • D — A home programme also delays necessary medical evaluation.

Concept being tested

8-10 scored items that exist only under Foundations for Evaluation, Differential Diagnosis and Prognosis. Multi-system presentations, medical red flags, medication effects on therapy and when to refer rather than treat. — 5% of the exam. Study guide for System Interactions.

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Primary references

  1. NPTE-PT Test Content Outline, effective January 2024 (v1.1) — Federation of State Boards of Physical Therapy (FSBPT) · primary · retrieved 2026-09-22, verified 2026-09-22
Last reviewed: 2026-10-07Reviewed by: Dr. Andrew Sullivan, PT, DPT, OCS, Physical therapy curriculum & clinical examination reviewHow we verify facts