NPTE Plan

Metabolic, Endocrine, GI, Genitourinary and Lymphatic Systems

10% of the NPTE · blueprint NPTE-PT content outline effective January 2024 (v1.1)

Short answer

These four smaller systems together carry 13-24 of the 180 scored items. The content covers diabetes and the exercise-related risks of hypoglycaemia and neuropathy, thyroid and adrenal disorders, gastrointestinal conditions that limit positioning and activity, bowel and bladder dysfunction and pelvic-floor rehabilitation, and lymphoedema staging with complete decongestive therapy and its contraindications.

Why it matters on this exam

Individually small, collectively bigger than the integumentary system, and frequently the reason an otherwise correct plan of care is unsafe.

Key concepts

Common mistakes

Worked example

A patient with type 1 diabetes reports shakiness and sweating 40 minutes into a session. Stop, check glucose, treat with 15 g of fast-acting carbohydrate and recheck in 15 minutes — continuing the session to "finish the set" is the wrong answer regardless of the plan of care.

Original practice questions

Metabolic, Endocrine, GI, Genitourinary and Lymphatic SystemsDifficulty 2/5

Forty minutes into a session a patient with type 1 diabetes becomes shaky, sweaty and anxious. What is the correct sequence?

  1. AEncourage rest and water, then resume when the symptoms settle
  2. BContinue with light activity because exercise will normalise glucose
  3. CFinish the current exercise set, then check glucose and provide juice
  4. DStop, check glucose, give 15 g of fast carbohydrate and recheck in 15 minutes
Show answer and rationale

Correct: D. These are hypoglycaemia symptoms. The response is to stop, test, treat with about 15 grams of fast-acting carbohydrate and retest after 15 minutes, repeating if still low.

  • C — Completing a set delays treatment of a falling glucose.
  • A — Water does not raise blood glucose.
  • B — Continued exercise lowers glucose further.
Metabolic, Endocrine, GI, Genitourinary and Lymphatic SystemsDifficulty 3/5

Which finding is a contraindication to manual lymphatic drainage and compression bandaging?

  1. AAcute cellulitis with fever and spreading erythema in the limb
  2. BPost-mastectomy oedema present for longer than twelve months
  3. CPitting oedema that reduces overnight with limb elevation
  4. DStage II lymphoedema with fibrotic tissue changes in the limb
Show answer and rationale

Correct: A. Acute infection is a contraindication to complete decongestive therapy; treating it can spread the infection. It is treated medically first, after which decongestive therapy resumes.

  • D — Fibrotic stage II lymphoedema is an indication for decongestive therapy.
  • B — Chronicity is not a contraindication.
  • C — Reducible pitting oedema is an early and treatable presentation.
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Related areas: Musculoskeletal System · Neuromuscular and Nervous Systems · Cardiovascular and Pulmonary Systems · Integumentary System

Primary references

  1. NPTE-PT Test Content Outline, effective January 2024 (v1.1) — Federation of State Boards of Physical Therapy (FSBPT) · primary · retrieved 2026-09-22, verified 2026-09-22
Last reviewed: 2026-09-22Next review by: 2026-12-21Draft — pending editorial reviewHow we verify facts